Tppp 抗体
Quick Overview for Tppp 抗体 (ABIN7271031)
抗原
See all Tppp 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- TPPP/p25 Rabbit mAb
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交叉反应
- 小鼠, 大鼠
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产品特性
- Monoclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- A synthesized peptide derived from human TPPP/p25
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亚型
- IgG
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anti-Tubulin Polymerization Promoting Protein (Tppp) (Internal Region) antibody
Verified Tppp 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Tubulin Polymerization Promoting Protein (Tppp) (AA 8-210) antibodyTppp 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tubulin Polymerization Promoting Protein (Tppp) (AA 1-219) antibodyTppp 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Tubulin Polymerization Promoting Protein (Tppp) antibodyTppp 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Tubulin Polymerization Promoting Protein (Tppp) (AA 1-219) antibodyTppp 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Tubulin Polymerization Promoting Protein (Tppp) (N-Term) antibodyTppp 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Tubulin Polymerization Promoting Protein (Tppp) (C-Term) antibodyTppp 适用: 小鼠, 大鼠, 犬, Cow, 豚鼠, 兔, Pig, 马, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Tubulin Polymerization Promoting Protein (Tppp) (C-Term) antibodyTppp 适用: 人, 小鼠, 大鼠, 犬, Cow, 兔, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Tubulin Polymerization Promoting Protein (Tppp) (N-Term) antibodyTppp 适用: 人, 犬, Cow, 豚鼠, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Tubulin Polymerization Promoting Protein (Tppp) (N-Term) antibodyTppp 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- Tppp (Tubulin Polymerization Promoting Protein (Tppp))
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别名
- TPPP
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背景
- Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath. Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath. Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes. Shows magnesium-dependent GTPase activity, the role of the GTPase activity is unclear. In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network. Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6. Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility. Plays a role in cell proliferation by regulating the G1/S-phase transition. Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis, this process is regulated by phosphorylation by LIMK2.,TPPP/p25, TPPP1, p24, p25, p25alpha,Cell Biology & Developmental Biology,Cytoskeleton,Cytoskeleton_Microtubules,Signal Transduction,TPPP
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分子量
- 25kDa
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基因ID
- 11076
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UniProt
- O94811
抗原
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