TMED2 抗体 (AA 60-170)
Quick Overview for TMED2 抗体 (AA 60-170) (ABIN7270943)
抗原
See all TMED2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 60-170
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原理
- TMED2 Rabbit pAb
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序列
- EITGPDNKGI YKGDRESSGK YTFAAHMDGT YKFCFSNRMS TMTPKIVMFT IDIGEAPKGQ DMETEAHQNK LEEMINELAV AMTAVKHEQE YMEVRERIHR AINDNTNSRV V
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 60-170 of human TMED2 (NP_006806.1).
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亚型
- IgG
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anti-Transmembrane Emp24 Domain Trafficking Protein 2 (TMED2) (AA 26-111) antibody
TMED2 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Emp24 Domain Trafficking Protein 2 (TMED2) (Center) antibodyTMED2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Emp24 Domain Trafficking Protein 2 (TMED2) (AA 50-79), (N-Term) antibodyTMED2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB32536 unconjugated
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应用备注
- WB,1:500 - 1:2000,IF,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- TMED2 (Transmembrane Emp24 Domain Trafficking Protein 2 (TMED2))
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别名
- TMED2
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背景
- Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor, the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs. Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.,P24A,RNP24,p24,p24b1,p24beta1,TMED2,Signal Transduction,Cell Biology & Developmental Biology,TMED2
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分子量
- 22kDa
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基因ID
- 10959
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UniProt
- Q15363
抗原
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