TGIF1 抗体 (AA 123-272)
Our Local Distributor
北京 101111
Quick Overview for TGIF1 抗体 (AA 123-272) (ABIN7270795)
抗原
See all TGIF1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 123-272
-
原理
- TGIF1 Rabbit pAb
-
序列
- VESVMGIKNF MPALEETPFH SCTAGPNPTL GRPLSPKPSS PGSVLARPSV ICHTTVTALK DVPFSLCQSV GVGQNTDIQQ IAAKNFTDTS LMYPEDTCKS GPSTNTQSGL FNTPPPTPPD LNQDFSGFQL LVDVALKRAA EMELQAKLTA
-
交叉反应
- 人, 小鼠, 大鼠
-
产品特性
- Polyclonal Antibodies
-
纯化方法
- Affinity purification
-
免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 123-272 of human TGIF1 (NP_003235.1).
-
亚型
- IgG
-
-
-
-
应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
-
-
- TGIF1 (TGFB-Induced Factor Homeobox 1 (TGIF1))
-
别名
- TGIF1
-
背景
- The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described.,TGIF1,HPE4,TGIF,Epigenetics & Nuclear Signaling,Transcription Factors,Nuclear Receptor Signaling,Signal Transduction,Cell Biology & Developmental Biology,Neuroscience,Stem Cells,Embryonic Stem Cells,Neural Stem Cells,Target gene,TGIF1
-
基因ID
- 7050
-
UniProt
- Q15583
-
途径
- Retinoic Acid Receptor Signaling Pathway, Chromatin Binding, Tube Formation
抗原
-