SEPN1 抗体 (AA 341-590)
Quick Overview for SEPN1 抗体 (AA 341-590) (ABIN7270196)
抗原
See all SEPN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 341-590
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原理
- SEPN1 Rabbit pAb
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序列
- VDMEWLYGAS ESSNMEVDIG YIPQMELEAT GPSVPSVILD EDGSMIDSHL PSGEPLQFVF EEIKWQQELS WEEAARRLEV AMYPFKKVSY LPFTEAFDRA KAENKLVHSI LLWGALDDQS CUGSGRTLRE TVLESSPILT LLNESFISTW SLVKELEELQ NNQENSSHQK LAGLHLEKYS FPVEMMICLP NGTVVHHINA NYFLDITSVK PEEIESNLFS FSSTFEDPST ATYMQFLKEG LRRGLPLLQP
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交叉反应
- 人, 小鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 341-590 of human SEPN1 (NP_065184.2).
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亚型
- IgG
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anti-Selenoprotein N, 1 (SEPN1) (C-Term) antibody
SEPN1 适用: 人, Cow, 豚鼠, 马, 大鼠, Pig, 斑马鱼, 猴, 犬 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Selenoprotein N, 1 (SEPN1) (C-Term) antibodySEPN1 适用: 人, 小鼠, Cow, Pig, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Selenoprotein N, 1 (SEPN1) (C-Term) antibodySEPN1 适用: 人, 小鼠, Cow, 豚鼠, 马, 大鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Selenoprotein N, 1 (SEPN1) (C-Term) antibodySEPN1 适用: 人, Cow, 豚鼠, 马, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Selenoprotein N, 1 (SEPN1) (AA 417-445), (C-Term) antibodySEPN1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB31326 unconjugated
anti-Selenoprotein N, 1 (SEPN1) (AA 416-445), (C-Term) antibodySEPN1 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- SEPN1 (Selenoprotein N, 1 (SEPN1))
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别名
- SEPN1
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背景
- This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in this gene are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. SEPN1-related myopathy consists of 4 autosomal recessive disorders, originally thought to be separate entities: rigid spine muscular dystrophy (RSMD1), the classical form of multiminicore disease, desmin related myopathy with Mallory-body like inclusions, and congenital fiber-type disproportion (CFTD). This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. Alternatively spliced transcript variants have been found for this gene.,SELENON,CFTD,MDRS1,RSMD1,RSS,SELN,SEPN1,SEPN1
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分子量
- 62kDa/65kDa
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基因ID
- 57190
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UniProt
- Q9NZV5
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途径
- Skeletal Muscle Fiber Development
抗原
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