SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8) 抗体
This anti- antibody is a 兔 单克隆 antibody detecting in WB 和 IF. Suitable for SARS Coronavirus-2 (SARS-CoV-2).
Quick Overview for SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8) 抗体 (ABIN7270150)
抗原
See all SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8) 抗体
SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8)
适用
SARS Coronavirus-2 (SARS-CoV-2)
宿主
兔
克隆类型
单克隆
标记
非结合性
应用范围
Western Blotting (WB), Immunofluorescence (IF)
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原理
- SARS-CoV-2 3CLpro Rabbit mAb
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交叉反应
- SARS Coronavirus-2 (SARS-CoV-2)
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产品特性
- Monoclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein of SARS-CoV-2 3CLpro.
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亚型
- IgG
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anti-SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8) antibody
SARS-CoV NSP8 适用: SARS Coronavirus-2 (SARS-CoV-2) WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000,IF,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- SARS-Coronavirus Nonstructural Protein 8 (SARS-CoV NSP8)
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别名
- 3CLpro
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物质类
- Viral Protein
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背景
- [Spike protein S1]: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein. Binding to host NRP1 and NRP2 via C-terminal polybasic sequence enhances virion entry into host cell. This interaction may explain virus tropism of human olfactory epithelium cells, which express high level of NRP1 and NRP2 but low level of ACE2. The stalk domain of S contains three hinges, giving the head unexpected orientational freedom. Uses human TMPRSS2 for priming in human lung cells which is an essential step for viral entry. Can be alternatively processed by host furin. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.,3CLpro
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基因ID
- 43740578
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UniProt
- P0DTC2
抗原
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