This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010],CHBL2, DCIP, HDDC1, MOP-5, SBBI88,Cell Biology & Developmental Biology,SAMHD1