RBM7 抗体 (AA 1-266)
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北京 101111
Quick Overview for RBM7 抗体 (AA 1-266) (ABIN7270088)
抗原
See all RBM7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-266
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原理
- RBM7 Rabbit pAb
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序列
- MGAAAAEADR TLFVGNLETK VTEELLFELF HQAGPVIKVK IPKDKDGKPK QFAFVNFKHE VSVPYAMNLL NGIKLYGRPI KIQFRSGSSH APQDVSLSYP QHHVGNSSPT STSPSRYERT MDNMTSSAQI IQRSFSSPEN FQRQAVMNSA LRQMSYGGKF GSSPLDQSGF SPSVQSHSHS FNQSSSSQWR QGTPSSQRKV RMNSYPYLAD RHYSREQRYT DHGSDHHYRG KRDDFFYEDR NHDDWSHDYD NRRDSSRDGK WRSSRH
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交叉反应
- 人, 小鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-266 of human RBM7 (NP_057174.1).
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亚型
- IgG
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anti-RNA Binding Motif Protein 7 (RBM7) (AA 196-222), (C-Term) antibody
RBM7 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB39651 unconjugated
anti-RNA Binding Motif Protein 7 (RBM7) (Middle Region) antibodyRBM7 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 犬, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-RNA Binding Motif Protein 7 (RBM7) (AA 180-229) antibodyRBM7 适用: 人, Cow, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- RBM7 (RNA Binding Motif Protein 7 (RBM7))
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别名
- RBM7
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背景
- RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs, enhancer RNAs (eRNAs, and 3'-extended products from small nuclear RNAs (snRNAs. Participates in several biological processes including DNA damage response (DDR and stress response. During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome. Participates in DNA damage response (DDR, through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability.,RBM7,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,RBM7
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基因ID
- 10179
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UniProt
- Q9Y580
抗原
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