PRKAB1 抗体
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北京 101111
Quick Overview for PRKAB1 抗体 (ABIN7269654)
抗原
See all PRKAB1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- AMPKβ1 Rabbit mAb
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Monoclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- A synthesized peptide derived from human AMPKbeta1
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亚型
- IgG
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应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- PRKAB1 (Protein Kinase, AMP-Activated, beta 1 Non-Catalytic Subunit (PRKAB1))
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别名
- PRKAB1
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背景
- The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008],AMPK, HAMPKb,AMPK Signaling Pathway,Autophagy,Autophagy_Regulator,Cancer,Cardiovascular,Cell Biology & Developmental Biology,Endocrine & Metabolism,Insulin Receptor Signaling Pathway,Kinase,Kinase_Serine/threonine kinases,Lipid Metabolism,Lipids,Lipids_Fatty Acids,PI3K-Akt Signaling Pathway,PI3K-Akt Signaling Pathway_Regulator of mTOR complex function,Protein phosphorylation,Signal Transduction,Warburg Effect,PRKAB1
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分子量
- 38kDa
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基因ID
- 5564
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UniProt
- Q9Y478
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途径
- AMPK Signaling, Warburg Effect
抗原
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