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PKN2 抗体

This anti-PKN2 antibody (ABIN7269646) is a Rabbit Monoclonal antibody detecting PKN2 in WB, IF. Suitable for Human.
产品编号 ABIN7269646
发货至: 中国

Quick Overview for PKN2 抗体 (ABIN7269646)

抗原

See all PKN2 抗体
PKN2 (Protein Kinase N2 (PKN2))

适用

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宿主

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克隆类型

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单克隆

标记

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This PKN2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF)
  • 原理

    PRK2/PKN2 Rabbit mAb

    交叉反应

    人, 小鼠, 大鼠

    产品特性

    Monoclonal Antibodies

    纯化方法

    Affinity purification

    免疫原

    A synthesized peptide derived from human PRK2/PRK2/PKN2

    亚型

    IgG
  • 应用备注

    WB,1:500 - 1:2000,IF,1:50 - 1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    PKN2 (Protein Kinase N2 (PKN2))

    别名

    PKN2

    背景

    PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF. Involved in the negative regulation of ciliogenesis.,PAK2, PRK2, PRKCL2, PRO2042, Pak-2, STK7,Epigenetics & Nuclear Signaling,Kinase,RNA Binding,Signal Transduction,PKN2

    分子量

    112kDa

    基因ID

    5586

    UniProt

    Q16513

    途径

    Cell-Cell Junction Organization
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