AF9 抗体 (AA 1-150)
Quick Overview for AF9 抗体 (AA 1-150) (ABIN7269603)
抗原
See all AF9 (MLLT3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-150
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原理
- MLLT3/AF9 Rabbit pAb
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序列
- MASSCAVQVK LELGHRAQVR KKPTVEGFTH DWMVFVRGPE HSNIQHFVEK VVFHLHESFP RPKRVCKDPP YKVEESGYAG FILPIEVYFK NKEEPRKVRF DYDLFLHLEG HPPVNHLRCE KLTFNNPTED FRRKLLKAGG DPNRSIHTSS
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human MLLT3/AF9 (NP_004520.2).
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亚型
- IgG
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anti-Protein AF-9 (MLLT3) (Center) antibody
MLLT3 适用: 人 WB, IHC (p), IF, ChIP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein AF-9 (MLLT3) (C-Term) antibodyMLLT3 适用: 人, 小鼠, Cow, 大鼠, 犬, 兔, 马, 斑马鱼, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein AF-9 (MLLT3) (C-Term) antibodyMLLT3 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Protein AF-9 (MLLT3) (AA 1-150) antibodyMLLT3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein AF-9 (MLLT3) (AA 1-568) antibodyMLLT3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3C11 unconjugated
anti-Protein AF-9 (MLLT3) (AA 471-502), (C-Term) antibodyMLLT3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB2249-2250 unconjugated
anti-Protein AF-9 (MLLT3) (N-Term) antibodyMLLT3 适用: 人, 小鼠, Cow, 大鼠, 犬, 兔, 马, 斑马鱼, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein AF-9 (MLLT3) (C-Term) antibodyMLLT3 适用: 人, 小鼠, Cow, 大鼠, 犬, 兔, 马, 斑马鱼, Pig, 豚鼠, 非洲爪蟾, 猴, Bat, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein AF-9 (MLLT3) (N-Term) antibodyMLLT3 适用: 人, 小鼠, Cow, 兔, 斑马鱼, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein AF-9 (MLLT3) (C-Term) antibodyMLLT3 适用: 人, 小鼠, 大鼠, 犬, 斑马鱼, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- AF9 (MLLT3) (Protein AF-9 (MLLT3))
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别名
- MLLT3
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背景
- Chromatin reader component of the super elongation complex (SEC, a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr, and with slightly lower affinity histone H3 crotonylated at 'Lys-18' (H3K18cr. Also recognizes and binds histone H3 acetylated and butyrylated at 'Lys-9' (H3K9ac and H3K9bu, respectively, but with lower affinity than crotonylated histone H3. In the SEC complex, MLLT3 is required to recruit the complex to crotonylated histones. Recruitment of the SEC complex to crotonylated histones promotes recruitment of DOT1L on active chromatin to deposit histone H3 'Lys-79' methylation (H3K79me. Plays a key role in hematopoietic stem cell (HSC maintenance by preserving, rather than confering, HSC stemness. Acts by binding to the transcription start site of active genes in HSCs and sustaining level of H3K79me2, probably by recruiting DOT1L.,MLLT3,AF9,YEATS3,Epigenetics & Nuclear Signaling,Cancer,MLLT3
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分子量
- 63kDa
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基因ID
- 4300
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UniProt
- P42568
抗原
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