This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14,21)(q11.2,q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008],BHLHB1, OLIGO2, PRKCBP2, RACK17, bHLHe19,Cell Type Marker,Cell Type Marker_Oligodendrocyte marker,Epigenetics & Nuclear Signaling,Neural Stem Cells,Neuroscience,Stem Cells,Transcription Factors,OLIG2