NXF1 抗体 (AA 57-356)
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北京 101111
Quick Overview for NXF1 抗体 (AA 57-356) (ABIN7269024)
抗原
See all NXF1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 57-356
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原理
- NXF1 Rabbit pAb
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序列
- GDVAMSDAQD GPRVRYNPYT TRPNRRGDTW HDRDRIHVTV RRDRAPPERG GAGTSQDGTS KNWFKITIPY GRKYDKAWLL SMIQSKCSVP FTPIEFHYEN TRAQFFVEDA STASALKAVN YKILDRENRR ISIIINSSAP PHTILNELKP EQVEQLKLIM SKRYDGSQQA LDLKGLRSDP DLVAQNIDVV LNRRSCMAAT LRIIEENIPE LLSLNLSNNR LYRLDDMSSI VQKAPNLKIL NLSGNELKSE RELDKIKGLK LEELWLDGNS LCDTFRDQST YIRSVVACVS PPGDLHPLGG
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 57-356 of human NXF1 (NP_001074960.1).
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亚型
- IgG
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应用备注
- WB,1:500 - 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- NXF1 (Nuclear RNA Export Factor 1 (NXF1))
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别名
- NXF1
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背景
- This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants.,NXF1,MEX67,TAP,Epigenetics & Nuclear Signaling,RNA Binding,NXF1
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分子量
- 40kDa/70kDa
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基因ID
- 10482
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UniProt
- Q9UBU9
抗原
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