NUAK1 抗体 (AA 362-661)
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北京 101111
Quick Overview for NUAK1 抗体 (AA 362-661) (ABIN7268966)
抗原
See all NUAK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 362-661
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原理
- NUAK1 Rabbit pAb
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序列
- LERQRSLKKS KKENDFAQSG QDAVPESPSK LSSKRPKGIL KKRSNSEHRS HSTGFIEGVV GPALPSTFKM EQDLCRTGVL LPSSPEAEVP GKLSPKQSAT MPKKGILKKT QQRESGYYSS PERSESSELL DSNDVMGSSI PSPSPPDPAR VTSHSLSCRR KGILKHSSKY SAGTMDPALV SPEMPTLESL SEPGVPAEGL SRSYSRPSSV ISDDSVLSSD SFDLLDLQEN RPARQRIRSC VSAENFLQIQ DFEGLQNRPR PQYLKRYRNR LADSSFSLLT DMDDVTQVYK QALEICSKLN
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交叉反应
- 人, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 362-661 of human NUAK1 (NP_055655.1).
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亚型
- IgG
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anti-NUAK Family, SNF1-Like Kinase, 1 (NUAK1) (AA 451-550) antibody
NUAK1 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-NUAK Family, SNF1-Like Kinase, 1 (NUAK1) (AA 1-661) antibodyNUAK1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-NUAK Family, SNF1-Like Kinase, 1 (NUAK1) (AA 1-30), (N-Term) antibodyNUAK1 适用: 人, 小鼠, Hamster WB, IHC (p) 宿主: 兔 Polyclonal RB3520 unconjugated
anti-NUAK Family, SNF1-Like Kinase, 1 (NUAK1) (AA 404-651) antibodyNUAK1 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-NUAK Family, SNF1-Like Kinase, 1 (NUAK1) (AA 604-634), (C-Term) antibodyNUAK1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB3521 unconjugated
anti-NUAK Family, SNF1-Like Kinase, 1 (NUAK1) antibodyNUAK1 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-NUAK Family, SNF1-Like Kinase, 1 (NUAK1) (Internal Region) antibodyVerified NUAK1 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-NUAK Family, SNF1-Like Kinase, 1 (NUAK1) (C-Term) antibodyNUAK1 适用: 人, 小鼠, 大鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-NUAK Family, SNF1-Like Kinase, 1 (NUAK1) (AA 421-658) antibodyNUAK1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:200 - 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- NUAK1 (NUAK Family, SNF1-Like Kinase, 1 (NUAK1))
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别名
- NUAK1
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背景
- Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1 complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair.,NUAK1,ARK5,Cancer,Signal Transduction,Kinase,Serine/threonine kinases,NUAK1
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分子量
- 23kDa/74kDa
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基因ID
- 9891
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UniProt
- O60285
抗原
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