Nemo-Like Kinase 抗体
Quick Overview for Nemo-Like Kinase 抗体 (ABIN7268846)
抗原
See all Nemo-Like Kinase (NLK) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- NLK Rabbit mAb
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Monoclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant protein of human NLK.
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亚型
- IgG
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anti-Nemo-Like Kinase (NLK) (AA 416-515) antibody
NLK 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 2B11 unconjugated
anti-Nemo-Like Kinase (NLK) antibodyNLK 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Nemo-Like Kinase (NLK) (AA 278-527) antibodyNLK 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nemo-Like Kinase (NLK) (AA 278-527) antibodyNLK 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nemo-Like Kinase (NLK) (AA 1-515) antibodyNLK 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Nemo-Like Kinase (NLK) (N-Term) antibodyNLK 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nemo-Like Kinase (NLK) (AA 408-436), (C-Term) antibodyNLK 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB34651 unconjugated
anti-Nemo-Like Kinase (NLK) (AA 275-300) antibodyNLK 适用: 人 WB, IF, FACS 宿主: 兔 Polyclonal RB16621 unconjugated
anti-Nemo-Like Kinase (NLK) (Thr286) antibodyNLK 适用: 人 WB, FACS, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-Nemo-Like Kinase (NLK) antibodyNLK 适用: 人 WB 宿主: 小鼠 Monoclonal 6C1 unconjugated
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应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- Nemo-Like Kinase (NLK)
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别名
- NLK
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背景
- Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner.,NLK, nemo like kinase,Epigenetics & Nuclear Signaling,Signal Transduction,Kinase,Serine/threonine kinases,Cell Biology & Developmental Biology,Cell Cycle,Wnt/β-Catenin Signaling Pathway,Stem Cells,NLK
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分子量
- 58kDa
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基因ID
- 51701
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UniProt
- Q9UBE8
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途径
- Ubiquitin Proteasome Pathway
抗原
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