MTMR6 抗体 (AA 382-621)
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北京 101111
Quick Overview for MTMR6 抗体 (AA 382-621) (ABIN7268765)
抗原
See all MTMR6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 382-621
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原理
- MTMR6 Rabbit pAb
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序列
- RCGQLDGDPK EVSPVFTQFL ECVWHLTEQF PQAFEFSEAF LLQIHEHIHS CQFGNFLGNC QKEREELKLK EKTYSLWPFL LEDQKKYLNP LYSSESHRFT VLEPNTVSFN FKFWRNMYHQ FDRTLHPRQS VFNIIMNMNE QNKQLEKDIK DLESKIKQRK NKQTDGILTK ELLHSVHPES PNLKTSLCFK EQTLLPVNDA LRTIEGSSPA DNRYSEYAEE FSKSEPAVVS LEYGVARMTC
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 382-621 of human MTMR6 (NP_004676.3).
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亚型
- IgG
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anti-Myotubularin Related Protein 6 (MTMR6) (AA 1-621) antibody
MTMR6 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Myotubularin Related Protein 6 (MTMR6) (AA 1-621) antibodyMTMR6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Myotubularin Related Protein 6 (MTMR6) (AA 531-580) antibodyMTMR6 适用: 人, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:200 - 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- MTMR6 (Myotubularin Related Protein 6 (MTMR6))
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别名
- MTMR6
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背景
- Phosphatase that acts on lipids with a phosphoinositol headgroup. Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3P and phosphatidylinositol 3,5-bisphosphate (Probable. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5P2 but also to phosphatidylinositol 3-phosphate (PtdIns(3P, phosphatidylinositol 4-phosphate (PtdIns(4P, and phosphatidylinositol 5-phosphate (PtdIns(5P, phosphatidic acid and phosphatidylserine. Negatively regulates ER-Golgi protein transport (By similarity. Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+ T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels.,MTMR6,Signal Transduction,MTMR6
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分子量
- 63kDa/71kDa
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基因ID
- 9107
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UniProt
- Q9Y217
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途径
- Inositol Metabolic Process
抗原
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