LAPTM4B 抗体 (AA 218-317)
Quick Overview for LAPTM4B 抗体 (AA 218-317) (ABIN7268341)
抗原
See all LAPTM4B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 218-317
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原理
- LAPTM4B Rabbit pAb
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序列
- NSIQEYIRQL PPNFPYRDDV MSVNPTCLVL IILLFISIIL TFKGYLISCV WNCYRYINGR NSSDVLVYVT SNDTTVLLPP YDDATVNGAA KEPPPPYVSA
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 218-317 of human LAPTM4B (NP_060877.3).
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亚型
- IgG
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anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (AA 174-226) antibody
LAPTM4B 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (AA 195-209) antibodyLAPTM4B 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal RB42294 unconjugated
anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (Internal Region) antibodyLAPTM4B 适用: 人, 大鼠, 小鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (Middle Region) antibodyLAPTM4B 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, 马, 兔, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal Protein Transmembrane 4 beta (LAPTM4B) (AA 216-265) antibodyLAPTM4B 适用: 人, 大鼠, 小鼠, 犬, 豚鼠, 马, 兔, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- LAPTM4B (Lysosomal Protein Transmembrane 4 beta (LAPTM4B))
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别名
- LAPTM4B
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背景
- Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter to the lysosome, promoting entry of leucine and other essential amino acid (EAA into the lysosome, stimulating activation of proton-transporting vacuolar (V-ATPase protein pump (V-ATPase and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways.,LAPTM4B,LAPTM4beta,LC27,Cancer,Tumor biomarkers,LAPTM4B
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分子量
- 25kDa/35kDa/41kDa
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基因ID
- 55353
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UniProt
- Q86VI4
抗原
-
