LYAR 抗体 (AA 10-160)
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北京 101111
Quick Overview for LYAR 抗体 (AA 10-160) (ABIN7268311)
抗原
See all LYAR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 10-160
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原理
- LYAR Rabbit pAb
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序列
- GESVKKIQVE KHVSVCRNCE CLSCIDCGKD FWGDDYKNHV KCISEDQKYG GKGYEGKTHK GDIKQQAWIQ KISELIKRPN VSPKVRELLE QISAFDNVPR KKAKFQNWMK NSLKVHNESI LDQVWNIFSE ASNSEPVNKE QDQRPLHPVA N
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 10-160 of human LYAR (NP_060286.1).
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亚型
- IgG
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anti-Ly1 Antibody Reactive (LYAR) (AA 270-388) antibody
LYAR 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ly1 Antibody Reactive (LYAR) (AA 1-379) antibodyLYAR 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Ly1 Antibody Reactive (LYAR) (AA 1-379) antibodyLYAR 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ly1 Antibody Reactive (LYAR) (AA 288-379) antibodyLYAR 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ly1 Antibody Reactive (LYAR) (AA 271-386) antibodyLYAR 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ly1 Antibody Reactive (LYAR) antibodyLYAR 适用: 人 WB 宿主: 小鼠 Monoclonal 25GB8235 unconjugated
anti-Ly1 Antibody Reactive (LYAR) antibodyLYAR 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ly1 Antibody Reactive (LYAR) (AA 179-228) antibodyLYAR WB 宿主: 兔 Polyclonal unconjugated
anti-Ly1 Antibody Reactive (LYAR) (AA 81-130) antibodyLYAR 适用: 人, 小鼠, 大鼠, 马, 豚鼠, 兔, 斑马鱼, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ly1 Antibody Reactive (LYAR) (AA 38-66), (N-Term) antibodyLYAR 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB18752 unconjugated
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应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- LYAR (Ly1 Antibody Reactive (LYAR))
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别名
- LYAR
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物质类
- Antibody
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背景
- Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs. Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2 promoter and represses its expression. In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA. Preferentially binds to a DNA motif containing 5'-GGTTAT-3'. Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity. In addition, inhibits NF-kappa-B-mediated expression of proinflammatory cytokines. Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity. Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs, which in turn is essential for ESC self-renewal (By similarity.,LYAR,ZC2HC2,ZLYAR,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,LYAR
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分子量
- 43kDa
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基因ID
- 55646
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UniProt
- Q9NX58
抗原
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