KLHDC2 抗体 (AA 1-240)
Quick Overview for KLHDC2 抗体 (AA 1-240) (ABIN7268073)
抗原
See all KLHDC2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-240
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原理
- KLHDC2 Rabbit pAb
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序列
- MADGNEDLRA DDLPGPAFES YESMELACPA ERSGHVAVSD GRHMFVWGGY KSNQVRGLYD FYLPREELWI YNMETGRWKK INTEGDVPPS MSGSCAVCVD RVLYLFGGHH SRGNTNKFYM LDSRSTDRVL QWERIDCQGI PPSSKDKLGV WVYKNKLIFF GGYGYLPEDK VLGTFEFDET SFWNSSHPRG WNDHVHILDT ETFTWSQPIT TGKAPSPRAA HACATVGNRG FVFGGRYRDA
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交叉反应
- 人
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human KLHDC2 (NP_055130.1).
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亚型
- IgG
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anti-Kelch Domain Containing 2 (KLHDC2) antibody
KLHDC2 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Kelch Domain Containing 2 (KLHDC2) antibodyKLHDC2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Kelch Domain Containing 2 (KLHDC2) (N-Term) antibodyKLHDC2 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Kelch Domain Containing 2 (KLHDC2) (AA 293-320), (C-Term) antibodyKLHDC2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB24802 unconjugated
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应用备注
- WB,1:500 - 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- KLHDC2 (Kelch Domain Containing 2 (KLHDC2))
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别名
- KLHDC2
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背景
- Substrate-recognition component of a Cul2-RING (CRL2 E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC2 complex specifically recognizes proteins with a diglycine (Gly-Gly at the C-terminus, leading to their ubiquitination and degradation. The CRL2(KLHDC2 complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine. The CRL2(KLHDC2 complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation. May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding.,KLHDC2,HCLP-1,HCLP1,LCP,Epigenetics & Nuclear Signaling,KLHDC2
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分子量
- 28kDa/46kDa
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基因ID
- 23588
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UniProt
- Q9Y2U9
抗原
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