FEM1A 抗体 (AA 100-300)
Quick Overview for FEM1A 抗体 (AA 100-300) (ABIN7267165)
抗原
See all FEM1A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 100-300
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原理
- FEM1A Rabbit pAb
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序列
- RSLLRRGASV NRTTRTNSTP LRAACFDGHL EVVRYLVGEH QADLEVANRH GHTCLMISCY KGHREIARYL LEQGAQVNRR SAKGNTALHD CAESGSLEIL QLLLGCKARM ERDGYGMTPL LAASVTGHTN IVEYLIQEQP GQEQVAGGEA QPGLPQEDPS TSQGCAQPQG APCCSSSPEE PLNGESYESC CPTSREAAVE A
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交叉反应
- 人, 小鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human FEM1A (NP_061178.1).
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亚型
- IgG
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anti-Fem-1 Homolog A (FEM1A) (AA 1-669) antibody
FEM1A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Fem-1 Homolog A (FEM1A) (C-Term) antibodyVerified FEM1A 适用: 人 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
anti-Fem-1 Homolog A (FEM1A) (AA 1-669) antibodyFEM1A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- FEM1A (Fem-1 Homolog A (FEM1A))
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别名
- FEM1A
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背景
- Substrate-recognition component of a Cul2-RING (CRL2 E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. Promotes ubiquitination and degradation of SLBP. Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4 (By similarity. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (By similarity.,FEM1A,EPRAP,Cell Biology & Developmental Biology,Apoptosis,Caspases,FEM1A
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分子量
- 73kDa
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基因ID
- 55527
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UniProt
- Q9BSK4
抗原
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