CARS 抗体
Quick Overview for CARS 抗体 (ABIN7266624)
抗原
See all CARS 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- CARS Rabbit mAb
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交叉反应
- 人, 大鼠
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产品特性
- Monoclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- A synthesized peptide derived from human CARS.
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亚型
- IgG
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anti-Cysteinyl-tRNA Synthetase (CARS) (AA 1-748) antibody
CARS 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Cysteinyl-tRNA Synthetase (CARS) (AA 201-500) antibodyCARS 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl-tRNA Synthetase (CARS) (AA 31-80) antibodyCARS 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl-tRNA Synthetase (CARS) (AA 661-710) antibodyCARS 适用: 人, 兔, Cow, Pig, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl-tRNA Synthetase (CARS) (N-Term) antibodyCARS 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl-tRNA Synthetase (CARS) (AA 469-748) antibodyCARS 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl-tRNA Synthetase (CARS) (C-Term) antibodyCARS 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl-tRNA Synthetase (CARS) (N-Term) antibodyCARS 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl-tRNA Synthetase (CARS) (C-Term) antibodyCARS 适用: 人, 小鼠, 大鼠, 兔, 犬, 马, Cow, 斑马鱼, Pig, Saccharomyces cerevisiae WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cysteinyl-tRNA Synthetase (CARS) antibodyCARS 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- CARS (Cysteinyl-tRNA Synthetase (CARS))
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别名
- CARS
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背景
- Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors.,CARS, CARS1, CYSRS, MGC:11246, cysteinyl-tRNA synthetase,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,Endocrine & Metabolism,Amino acid metabolism,Nucleotide metabolism,CARS
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分子量
- 75kDa
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基因ID
- 833
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UniProt
- P49589
抗原
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