CCDC47 抗体 (AA 224-483)
This anti-CCDC47 antibody is a 兔 多克隆 antibody detecting CCDC47 in WB 和 IF. Suitable for 人.
Quick Overview for CCDC47 抗体 (AA 224-483) (ABIN7266438)
抗原
See all CCDC47 抗体
CCDC47
(Coiled-Coil Domain Containing 47 (CCDC47))
适用
人
宿主
兔
克隆类型
多克隆
标记
This CCDC47 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunofluorescence (IF)
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抗原表位
- AA 224-483
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原理
- CCDC47 Rabbit pAb
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序列
- FLKRQDLLNV LARMMRPVSD QVQIKVTMND EDMDTYVFAV GTRKALVRLQ KEMQDLSEFC SDKPKSGAKY GLPDSLAILS EMGEVTDGMM DTKMVHFLTH YADKIESVHF SDQFSGPKIM QEEGQPLKLP DTKRTLLFTF NVPGSGNTYP KDMEALLPLM NMVIYSIDKA KKFRLNREGK QKADKNRARV EENFLKLTHV QRQEAAQSRR EEKKRAEKER IMNEEDPEKQ RRLEEAALRR EQKKLEKKQM KMKQIKVKAM
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 224-483 of human CCDC47 (NP_064583.2).
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亚型
- IgG
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anti-Coiled-Coil Domain Containing 47 (CCDC47) (AA 375-483) antibody
CCDC47 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Coiled-Coil Domain Containing 47 (CCDC47) (C-Term) antibodyCCDC47 适用: 人, 小鼠, 大鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000,IF,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- CCDC47 (Coiled-Coil Domain Containing 47 (CCDC47))
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别名
- CCDC47
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背景
- Component of the PAT complex, an endoplasmic reticulum (ER-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs, releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. WDR83OS/Asterix is the substrate-interacting subunit of the PAT complex, whereas CCDC47 is required to maintain the stability of WDR83OS/Asterix. The PAT complex favors the binding to TMDs with exposed hydrophilic amino acids within the lipid bilayer and provides a membrane-embedded partially hydrophilic environment in which the first transmembrane domain binds. Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. Involved in the regulation of calcium ion homeostasis in the ER. Required for proper protein degradation via the ERAD (ER-associated degradation pathway. Has an essential role in the maintenance of ER organization during embryogenesis (By similarity.,CCDC47,GK001,MSTP041,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,CCDC47
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分子量
- 55kDa
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基因ID
- 57003
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UniProt
- Q96A33
抗原
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