C9ORF72 抗体 (AA 1-230)
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北京 101111
Quick Overview for C9ORF72 抗体 (AA 1-230) (ABIN7266391)
抗原
See all C9ORF72 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-230
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原理
- C9orf72 Rabbit pAb
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序列
- MSTLCPPPSP AVAKTEIALS GKSPLLAATF AYWDNILGPR VRHIWAPKTE QVLLSDGEIT FLANHTLNGE ILRNAESGAI DVKFFVLSEK GVIIVSLIFD GNWNGDRSTY GLSIILPQTE LSFYLPLHRV CVDRLTHIIR KGRIWMHKER QENVQKIILE GTERMEDQGQ SIIPMLTGEV IPVMELLSSM KSHSVPEEID IADTVLNDDD IGDSCHEGFL LNAISSHLQT
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human C9orf72 (NP_060795.1).
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亚型
- IgG
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anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 391-481) antibody
C9ORF72 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 138-430) antibodyC9ORF72 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 396-424), (C-Term) antibodyC9ORF72 适用: 人 WB 宿主: 兔 Polyclonal RB27382 unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 1-481) antibodyC9ORF72 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 396-424) antibodyC9ORF72 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))
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别名
- C9orf72
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背景
- The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms.,C9orf72,ALSFTD,DENNL72,FTDALS,FTDALS1,Epigenetics & Nuclear Signaling,Transcription Factors,Neuroscience,Neurodegenerative Diseases,Neurodegenerative Diseases Markers,Other Neurological disorders,Amyotrophic lateral sclerosis-ALS,C9orf72
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分子量
- 24kDa/54kDa
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基因ID
- 203228
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UniProt
- Q96LT7
抗原
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