CDH1,CDH2,CDH3,CDH4 (AA 800-882) 抗体
The 兔 多克隆 anti-CDH1,CDH2,CDH3,CDH4 antibody is suitable to detect CDH1,CDH2,CDH3,CDH4 in samples from 人. It has been validated for WB 和 IP.
产品编号 ABIN7266233
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
Quick Overview for CDH1,CDH2,CDH3,CDH4 (AA 800-882) 抗体 (ABIN7266233)
抗原
CDH1,CDH2,CDH3,CDH4
适用
人
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
Western Blotting (WB), Immunoprecipitation (IP)
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抗原表位
- AA 800-882
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原理
- Pan Cadherin Rabbit pAb
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- A synthetic peptide corresponding to a sequence within amino acids 800-882 of pan-cadherin (NP_004351.1).
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亚型
- IgG
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anti-CDH1,CDH2,CDH3,CDH4 antibody
适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
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应用备注
- WB,1:500 - 1:2000,IP,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- CDH1,CDH2,CDH3,CDH4
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别名
- CDH1/CDH2/CDH3/CDH4
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背景
- Cadherin is one of a class of integral-membrane glycoproteins that are involved in cell to cell attachment for preserving the integrity of all solid tissues. Cadherins have three major regions: the Ca2+ -dependent extracellular region that mediates adhesion (cadherin to cadherin) for cell to cell binding, the transmembrane region, and the cytoplasmic region that extends into the cell and interacts with catenins, which in turn are linked to the actin of the cytoskeleton. Cadherins are differentially expressed during development and in adult organs. Since many cell types express multiple cadherin subclasses simultaneously (the combination differs with cell type), it can be inferred that the adhesion properities of individual cells are thus governed by varying the combinations of cadherins. Altered expression of cadherins are involved in invasion and metastasis of tumour cells. The classical cadherins (e.g. E-, N-, and P-cadherins) are the most common family members. E-cadherin (also known as uvomorulin) is concentrated in the belt desmosome in epithelial cells, N-cadherin is found in nerve, muscle, and lens cells and helps maintain the integrity of neuronal aggregates, P-cadherin is expressed in placental and epidermal cells.,CDH1/CDH2/CDH3/CDH4
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基因ID
- 999, 1000, 1001
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UniProt
- P12830, P19022, P22223, P55283
抗原
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