TMC1 抗体 (Extracellular)
Quick Overview for TMC1 抗体 (Extracellular) (ABIN7237916)
抗原
See all TMC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Extracellular
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原理
- A Rabbit Polyclonal antibody to TMC1 (extracellular)
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特异性
- Extracellular, 3rd loop.
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,human - identical
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产品特性
- Extracellular, 3rd loop
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)EHDFPSWMAKILR, corresponding to amino acid residues 679 - 691 of mouse TMC1
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亚型
- IgG
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anti-Transmembrane Channel-Like 1 (TMC1) antibody
TMC1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transmembrane Channel-Like 1 (TMC1) (AA 600-700) antibodyTMC1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200-1:400
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说明
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Negative Control: (ABIN7237509)
Blocking Peptide: (ABIN7237509)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- TMC1 (Transmembrane Channel-Like 1 (TMC1))
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别名
- TMC1
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背景
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Transmembrane Channel Like 1, Transmembrane cochlear-expressed protein 1,Transmembrane channel-like protein 1 (TMC1) is one of eight mammalian TMC genes. Proteins that belong to this family contain six transmembrane domains with both the C and N termini on the cytoplasmic side of the membrane, as well as a large loop between domains 4 and 5. This multi-pass transmembrane topologic structure suggests roles as a receptor, transporter, channel, or pump1. TMC1 and the closely related TMC2 gene are assembled as dimers2 and are expressed in neurosensory hair cells of the mouse inner ear where they appear to have a role as pore forming units in mechanoelectrical transduction. Mutations of the transmembrane channel-like 1 (TMC1) gene can cause dominant and recessive forms of deafness in humans and mice3 and hence, identification of the molecular functions of Tmc genes is broadly significant because it may provide a handle on the fundamental mechanisms that mediate human hearing and balance4.
Alternative names: Transmembrane Channel Like 1, Transmembrane cochlear-expressed protein 1 -
基因ID
- 13409
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NCBI登录号
- NM_138691
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UniProt
- Q8R4P5
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途径
- Sensory Perception of Sound
抗原
-
