Tetraspanin 7 抗体 (Extracellular, Loop 2)
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Quick Overview for Tetraspanin 7 抗体 (Extracellular, Loop 2) (ABIN7237885)
抗原
See all Tetraspanin 7 (TSPAN7) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 155-169, Extracellular, Loop 2
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原理
- A Rabbit Polyclonal Antibody to Tetraspanin 7 (extracellular)
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - 15 out of 16 amino acid residues identical, rat - 14 out of 16 amino acid residues identical
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产品特性
- Extracellular, 2nd loop
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)DWENTDWFKETKNQS, corresponding to amino acid residues 155 - 169 of human Tetraspanin-3
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亚型
- IgG
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anti-Tetraspanin 7 (TSPAN7) (AA 113-223) antibody
TSPAN7 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tetraspanin 7 (TSPAN7) (AA 98-124) antibodyTSPAN7 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB22231 unconjugated
anti-Tetraspanin 7 (TSPAN7) (AA 113-212) antibodyTSPAN7 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Tetraspanin 7 (TSPAN7) (AA 113-213) antibodyTSPAN7 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Tetraspanin 7 (TSPAN7) antibody (APC)TSPAN7 适用: 人 FACS 宿主: 小鼠 Monoclonal B2D APC
anti-Tetraspanin 7 (TSPAN7) antibodyTSPAN7 适用: 人 WB, FACS, IHC, IP 宿主: 小鼠 Monoclonal B2D unconjugated
anti-Tetraspanin 7 (TSPAN7) antibody (PE)TSPAN7 适用: 人 FACS 宿主: 小鼠 Monoclonal B2D PE
anti-Tetraspanin 7 (TSPAN7) antibody (FITC)TSPAN7 适用: 人 FACS 宿主: 小鼠 Monoclonal B2D FITC
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应用备注
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WB: 1:400-1:500
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7237381)
Blocking Peptide: (ABIN7237381)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Tetraspanin 7 (TSPAN7)
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别名
- TSPAN7
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背景
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Synonyms: TSPAN7, Transmembrane 4 Superfamily Member 2, TM4SF2, T-Cell Acute Lymphoblastic Leukemia-Associated Antigen 1, TALLA-1, Cell Surface Glycoprotein A15, A15, CD231.
Description: Tetraspanins (Tspans) are a family of four-span transmembrane proteins, known as plasma membrane "master organizers." They form Tspan-enriched microdomains (TEMs or TERMs) through lateral association with one another and other membrane proteins.1Tetraspanins are characterized by four transmembrane domains, two extracellular loops: one small extracellular loop (SEL or EC1) and one larger extracellular loop (LEL or EC2), a short intracellular loop, and two short intracellular tails.1Teatraspanin 7 (TSPAN7) is highly expressed in the brain and was first described as a candidate gene for X-linked intellectual disability, probably through the modulation of surface expression of AMPA and dopamine receptors.2Tetraspanin 7 also has a key role in controlling pancreatic β-cell Ca2+ handling and defining the set-point of insulin secretion through modulation of L-type Cav1.2 and Cav1.3 channels. Furthermore, it has been identified as a target for autoantibodies in Type I diabetes. 3In addition, Tetraspanin 7 is involved in the regulation of HIV virus entry into dendritic cells and several types of cancer progression. 2
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基因ID
- 7102
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NCBI登录号
- NM_004615
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UniProt
- P41732
抗原
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