SCN4B 抗体 (Extracellular)
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Quick Overview for SCN4B 抗体 (Extracellular) (ABIN7237813)
抗原
See all SCN4B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 85-98, Extracellular
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原理
- A Rabbit Polyclonal Antibody to NaVβ4 Subunit
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特异性
- Extracellular, N-terminus
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse - identical, human - 11,14 amino acid residues identical
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产品特性
- Extracellular, N-terminus
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KNDKSDPKVRVKDD, corresponding to amino acid residues 85-98 of rat beta4 subunit of voltage-gated Na+ channels
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亚型
- IgG
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anti-Sodium Channel, Voltage-Gated, Type IV, beta Subunit (SCN4B) antibody
SCN4B 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sodium Channel, Voltage-Gated, Type IV, beta Subunit (SCN4B) antibodySCN4B 适用: 大鼠, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sodium Channel, Voltage-Gated, Type IV, beta Subunit (SCN4B) (Internal Region) antibodySCN4B 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sodium Channel, Voltage-Gated, Type IV, beta Subunit (SCN4B) (AA 31-162) antibodySCN4B 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Sodium Channel, Voltage-Gated, Type IV, beta Subunit (SCN4B) antibodySCN4B 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Sodium Channel, Voltage-Gated, Type IV, beta Subunit (SCN4B) (C-Term) antibodySCN4B 适用: 人 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:800
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说明
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Negative Control: (ABIN7236855)
Blocking Peptide: (ABIN7236855)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- SCN4B (Sodium Channel, Voltage-Gated, Type IV, beta Subunit (SCN4B))
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别名
- SCN4B
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背景
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Voltage-gated sodium channel subunit beta-4, LQT10,Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability1. NaV channels are activated in response to depolarization and selectively allow the flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.94,5. NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9) 2,3.Mammalian Na+ channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. Na+ channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas Na+ channels in adult skeletal muscle have only the β1 subunit6,7.NaVβ4 has been associated with Long QT syndrome8 and with Huntington's disease, showing a distinct down regulation of NaVβ4 in the presymptomatic stage of HD mice, whereas other voltage-gated ion channel subunits were later decreased9.
Alternative names: SCN4B (NaVbeta4), Voltage-gated sodium channel subunit beta-4, LQT10, -
基因ID
- 315611
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NCBI登录号
- NM_001142348
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UniProt
- Q7M730
抗原
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