Netrin 3 抗体 (Secreted)
Quick Overview for Netrin 3 抗体 (Secreted) (ABIN7237732)
抗原
See all Netrin 3 (Ntn3) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 445-458, Secreted
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原理
- A Rabbit Polyclonal antibody to Netrin-3
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特异性
- Secreted
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat - identical, Human - 13 out of 14 amino acid residues identical
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产品特性
- Secreted
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: Peptide CRPARGSYRISLKK, corresponding to amino acid residues 445 - 458 of mouse Netrin-3
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亚型
- IgG
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:1000
Application Dilutions Western blot wb: 1:200-1:400
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说明
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Negative Control: (ABIN7236014)
Blocking Peptide: (ABIN7236014)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- Netrin 3 (Ntn3)
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别名
- NTN3
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背景
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NTN3, Netrin-2-Like Protein, NTN2L,Netrins are a family of highly conserved proteins responsible for axon guidance and cell movement throughout neural development. Netrins can be divided into secreted netrins (netrin 1,3,4 and 5) and membrane-tethered glycophosphatidylinositol (GPI)-linked netrins (netrin G1 and G2)1.Secreted netrins carry their function via interaction with several receptors that include the deleted in colorectal (DCC) family, and the uncoordinated-5 (UNC5-A through UNC5-D) family2.Netrin-3 was discovered in 1997 using sequence homology searching of netrin-2. Similarly to other netrins, Netrin-3 plays an important role in the development of the nervous system. Netrin-3 structure consist of a laminin-like domain located on the N-terminal, three epidermal growth factors like repeats (EGF), and a C-terminal netrin-like domain (NTR). Mutations in NTN3, the gene encoding netrin-3 was found to be associated with the development of several carcinomas3.
Alternative names: NTN3, Netrin-2-Like Protein, NTN2L -
基因ID
- 18209
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NCBI登录号
- NM_006181
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UniProt
- Q9R1A3
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途径
- Regulation of Muscle Cell Differentiation
抗原
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