NEO1 抗体 (Extracellular, N-Term)
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Quick Overview for NEO1 抗体 (Extracellular, N-Term) (ABIN7237724)
抗原
See all NEO1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 701-715, Extracellular, N-Term
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原理
- A Rabbit Polyclonal antibody to Neogenin (extracellular)
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Human,rat - identical
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产品特性
- Extracellular, N-terminus
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KIRYRKASRKSDVTE, corresponding to amino acid residues 701 - 715 of mouse Neogenin
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亚型
- IgG
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anti-Neogenin 1 (NEO1) (AA 414-682) antibody
NEO1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Neogenin 1 (NEO1) (AA 701-715), (Extracellular), (N-Term) antibody (FITC)NEO1 适用: 小鼠 FACS, LCI 宿主: 兔 Polyclonal FITC
anti-Neogenin 1 (NEO1) (AA 21-70) antibodyNEO1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Neogenin 1 (NEO1) (AA 1411-1461) antibodyNEO1 适用: 人, 小鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Neogenin 1 (NEO1) (AA 657-685) antibodyNEO1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB37040 unconjugated
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应用备注
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WB: 1:200
FC: 2.5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235994)
Blocking Peptide: (ABIN7235994)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- NEO1 (Neogenin 1 (NEO1))
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别名
- NEO1
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背景
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Synonyms: Neogenin 1, NEO1, NGN
Description: Neogenin also known as NEO1 is a member of the immunoglobulin (Ig) superfamily. It has been reported to be involved in diverse physiology and pathology functions, including cell proliferation, differentiation and migration1. Neogenin was originally isolated from embryonic chicken cerebellum and reported to be homologous to the axon guidance receptor deleted in colorectal cancer (DCC)2.Neogenin consists of 4 N-terminal Ig-like domains, followed by 6 fibronectin type III-like domains, a single transmembrane helix, and an intracellular domain. Neogenin is capable to mediate attractive and repulsive axon guidance depending on the ligand identity. Two main ligands of neogenin are Netrin-1 (NET1) and repulsive guidance molecules (RGMs)3.Interaction of Neogenin with RGMs leads to cytoskeleton rearrangements via Rho GTPases, this results in growth cone collapse. In contrast interaction with Netrin-1 triggers attractive growth cone response3. Recently it was shown that Neogenin plays a role in the maintenance of iron homeostasis via interaction with HJV (members of the RGM family)4.
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基因ID
- 18007
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NCBI登录号
- NM_002499
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UniProt
- P97798
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途径
- Transition Metal Ion Homeostasis, Regulation of Muscle Cell Differentiation, Tube Formation
抗原
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