MRGPRD 抗体 (Intracellular)
Quick Overview for MRGPRD 抗体 (Intracellular) (ABIN7237719)
抗原
See all MRGPRD 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 285-299, Intracellular
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原理
- A Guinea Pig Polyclonal Antibody to MRGPRD (GPCR TGR7) Receptor
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特异性
- Intracellular, C-terminus
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交叉反应
- 小鼠, 大鼠
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预测反应
- Mouse - identical It will not recognize MRGPRD from human samples
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产品特性
- Intracellular, C-terminus
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)KSHRLQESLGAVLGR, corresponding to amino acid residues 285-299 of rat MRGPRD
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亚型
- IgG
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anti-MAS-Related GPR, Member D (MRGPRD) (Cytoplasmic Domain) antibody
MRGPRD 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-MAS-Related GPR, Member D (MRGPRD) (Extracellular Domain) antibodyMRGPRD 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-MAS-Related GPR, Member D (MRGPRD) (Cytoplasmic Domain) antibodyMRGPRD 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-MAS-Related GPR, Member D (MRGPRD) (C-Term) antibodyMRGPRD 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:500-1:800
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- MRGPRD (MAS-Related GPR, Member D (MRGPRD))
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别名
- MRGPRD
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背景
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Mrgd, Mas-related G-protein coupled receptor member D, G-protein coupled receptor TGR7, β-Alanine receptor,Mas-related G-protein coupled receptor member D (MRGPRD) is expressed in the dorsal root ganglia, specifically in non-peptidergic, small-diameter, IB4+ C-fiber neurons that innervate the outer layers of the mammalian skin. They transmit polymodal nociceptive information from the skin epidermis to the substantia gelatinosa of the spinal cord.MRGPRD receptor expressing neurons are essential for the full expression of mechanical nociception. Thus, MRGPRD represents an attractive therapeutic target for the development of agents for treating pain1,2.The Mrg family in mice is comprised of six single-copy genes: MrgD, MrgE, MrgF/RTA, MrgG, MrgH/GPR90, and MAS1. In addition, there are three large subfamilies: MrgA, MrgB,and MrgC3.MRGPRD receptor is activated by β-alanine and is able to inhibit KCNQ/M-type potassium channels and to increase excitability of sensory neurons4,5. MRGPRD has the ability to form heterodimers and is encoded by the TGR7 gene. This receptor is co-expressed with two nociceptors, including purinergic receptor (P2X3) and a vanilloid receptor (VR1)5.
Alternative names: Mrgd, Mas-related G-protein coupled receptor member D, G-protein coupled receptor TGR7, β-Alanine receptor -
基因ID
- 293648
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NCBI登录号
- NM_198923
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UniProt
- Q7TN41
抗原
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