LRRTM2 抗体 (Extracellular)
Quick Overview for LRRTM2 抗体 (Extracellular) (ABIN7237710)
抗原
See all LRRTM2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 47-61, Extracellular
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原理
- A Rabbit Polyclonal antibody to LRRTM2 (extracellular)
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特异性
- Extracellular, N-terminus.
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat,human - identical
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产品特性
- Extracellular, N-terminus
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: Peptide CDSQGFHSVPNATDK, corresponding to amino acid residues 47 - 61 of mouse LRRTM2
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亚型
- IgG
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:400
Application Dilutions Western blot wb: 1:200-1:400
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说明
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Negative Control: (ABIN7235871)
Blocking Peptide: (ABIN7235871)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- LRRTM2 (Leucine Rich Repeat Transmembrane Neuronal 2 (LRRTM2))
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别名
- LRRTM2
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背景
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Leucine-rich repeat transmembrane neuronal protein 2, Leucine-Rich Repeat Neuronal 2 Protein, LRRN2,Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) function as postsynaptic organizers that induce excitatory synapses. There are four related LRRTM genes in mammals, and all are enriched in brain and expressed from postnatal day one or earlier1. LRRTM2 is the most synaptogenic isoform of the family, and its expression is strongly restricted to excitatory synapses in mature neurons. It consists of leucine-rich repeat (LRR) domain in the N-terminal extracellular domain, followed by a single transmembrane domain and a cytoplasmic region contains a PDZ domain binding motif2. LRRTM2 can induce clustering of NMDA receptors, PSD-95 and SynGAP in postsynaptic membrane. PSD-95 function as a scaffold to cluster these postsynaptic proteins. It was found that LRRTM2 deletion in mice leading to dramatically impairs basal synaptic transmission and disrupts long-term potentiation, a prominent form of synaptic plasticity that is critical for learning and memory3. LRRTM2 responsible for the structural linkage mediating nanocolumn alignment of AMPARs, a protein critical for the strength of basal synaptic transmission3.
Alternative names: Leucine-rich repeat transmembrane neuronal protein 2, Leucine-Rich Repeat Neuronal 2 Protein, LRRN2 -
基因ID
- 107065
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NCBI登录号
- NM_015564
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UniProt
- Q8BGA3
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途径
- Synaptic Membrane
抗原
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