LRRC4 抗体 (Extracellular)
Quick Overview for LRRC4 抗体 (Extracellular) (ABIN7237706)
抗原
See all LRRC4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 507-520, Extracellular
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原理
- A Rabbit Polyclonal antibody to NGL-2/LRRC4 (extracellular)
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特异性
- Extracellular, N-terminus.
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Rat - identical,Human 13 out of 14 amino acid residues identical
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产品特性
- Extracellular, N-terminus
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)STDTTDKMQTSLDE, corresponding to amino acid residues 507 - 520 of mouse LRRC4
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亚型
- IgG
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anti-Leucine Rich Repeat Containing 4 (LRRC4) (AA 531-559), (C-Term) antibody
LRRC4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB24095 unconjugated
anti-Leucine Rich Repeat Containing 4 (LRRC4) (AA 1-602) antibodyLRRC4 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Leucine Rich Repeat Containing 4 (LRRC4) (AA 544-653) antibodyLRRC4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Leucine Rich Repeat Containing 4 (LRRC4) (AA 536-565), (C-Term) antibodyLRRC4 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:200
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7235857)
Blocking Peptide: (ABIN7235857)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- LRRC4 (Leucine Rich Repeat Containing 4 (LRRC4))
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别名
- LRRC4
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背景
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Netrin-G2 Ligand, Brain Tumor-Associated Protein BAG, Leucine-Rich Repeat-Containing Protein 4,The leucine-rich repeat (LRR) superfamily is a diverse protein family that consist of leucine-rich domains (LRR domains). The LRR domain is known to regulate protein-protein interaction or cell adhesion. Large portion of LRR proteins mediate the differentiation and development of nervous tissues1. One member of the LRR superfamily is leucine rich repeat containing protein 4 (LRRC4), also known as netrin-G ligand-2 (NGL-2), and serves as a receptor for netrin-G2 (NTNG2). In addition to the LRR domain LRRC4 consist of immunoglobulin (Ig) domain in the extracellular region, a transmembrane domain, and a cytoplasmic region that terminates in a protein-protein interaction domain (PDZ)-binding motif. LRRC4 regulates the formation of excitatory synapses and promotes axon differentiation2.Functionally, deletion of LRRC4 in mice was found to suppress excitatory synapse development and synaptic transmission. In addition, LRRC4 gene has been identified as tumor suppressor3. In human it has been implicated in autism spectrum disorder (ASD), schizophrenia, and intellectual disability. Moreover, netrin-G2, the presynaptic ligand of LRRC4, is linked to schizophrenia and bipolar disorder4-5.
Alternative names: Netrin-G2 Ligand, Brain Tumor-Associated Protein BAG, Leucine-Rich Repeat-Containing Protein 4 -
基因ID
- 192198
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NCBI登录号
- NM_022143
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UniProt
- Q99PH1
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途径
- Synaptic Membrane
抗原
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