HOMER1 抗体 (Intracellular)
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Quick Overview for HOMER1 抗体 (Intracellular) (ABIN7237693)
抗原
See all HOMER1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 293-296, Intracellular
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原理
- A Guinea Pig Polyclonal Antibody to Homer1
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交叉反应
- 人, 小鼠, 大鼠
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交叉反应 （详细）
- The antibody will not recognize Homer1 short isoform 3 (also known as Homer1a), but will recognize isoform 2 (also known as Homer1b).
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预测反应
- Mouse,human - identical
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产品特性
- Intracellular
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KQEIDNARELQEQR, corresponding to amino acid residues 293-296 of rat Homer1
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亚型
- IgG
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anti-Homer Homolog 1 (HOMER1) (Center) antibody
HOMER1 适用: 人, 小鼠, 大鼠 WB, ICC, IP, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 1-354) antibodyHOMER1 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) antibodyKD Validated HOMER1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB6005 unconjugated Recombinant Antibody
anti-Homer Homolog 1 (HOMER1) antibodyHOMER1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 96-122), (N-Term) antibodyHOMER1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB18229 unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 1-354) antibodyHOMER1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 101-150) antibodyHOMER1 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, Pig, 猴, Bat, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 1-354) antibodyHOMER1 适用: 人 WB, ELISA, ICC, IF 宿主: 小鼠 Monoclonal AT1F3 unconjugated
anti-Homer Homolog 1 (HOMER1) antibodyHOMER1 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Homer Homolog 1 (HOMER1) (AA 1-354) antibodyHOMER1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal AT1F3 unconjugated
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应用备注
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WB: 1:400
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:100
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235762)
Blocking Peptide: (ABIN7235762)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- HOMER1 (Homer Homolog 1 (HOMER1))
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别名
- HOMER1
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背景
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Synonyms: Homer protein homolog 1, Homer scaffolding protein 1, Vesl-1, Ves 1, PSD-Zip45, SYN47
Description: Homer proteins regulate signal transduction, generation of synapses and receptor trafficking. The homer protein family is comprised of three members with each member alternatively spliced to long and short forms. All members of the Homer family are synaptic scaffolding proteins with an N-terminal EVH (Ena/VASP homology 1) and a C-terminal coiled-coil domain. Long forms of the protein contain both EVH1 and coiled-coil domains and are constitutively expressed, whereas the short forms contain only the EVH1 domain and are expressed in an activity dependent manner1.The long form of Homer1 assembles group 1 metabotropic glutamate receptors mGluR1 and mGluR5 in large macromolecular complexes at synapses as well as with components of the NMDA receptor complex at the neuronal cell membrane. In contrast, the short form of Homer1 lacks the ability of linking mGluR1/5 to synaptic proteins and functions as an endogenous negative modulator of the mGluR1/5-inositol 1,4,5-trisphosphate receptor signaling complex. Transgenic mice with overexpressed Homer1 in striatal medium spiny neurons demonstrate normal development of striatal structure and afferent/efferent connectivity. However, motor performance in behavioral tasks and striatal responses to the psychomotor stimulant amphetamine are significantly altered in these mice2.At concentrations
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基因ID
- 29546
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NCBI登录号
- NM_004272
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UniProt
- Q9Z214
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途径
- Skeletal Muscle Fiber Development
抗原
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