GJC2 抗体 (Intracellular Loop)
Our Local Distributor
北京 101111
Quick Overview for GJC2 抗体 (Intracellular Loop) (ABIN7237684)
抗原
See all GJC2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 100-111, Intracellular Loop
-
原理
- A Rabbit Polyclonal antibody to Connexin-47 (GJC2)
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- Mouse,human - identical
-
产品特性
- Intracellular loop
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
- (C)HRLARASEQERR, corresponding to amino acid residues 100 - 111 of rat Connexin-47
-
亚型
- IgG
-
-
anti-Gap Junction Protein, gamma 2, 47kDa (GJC2) (Middle Region) antibody
GJC2 适用: 人, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, gamma 2, 47kDa (GJC2) (N-Term) antibodyGJC2 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, gamma 2, 47kDa (GJC2) (N-Term) antibodyGJC2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, gamma 2, 47kDa (GJC2) (C-Term) antibodyGJC2 适用: 人, 兔, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, gamma 2, 47kDa (GJC2) antibodyGJC2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Gap Junction Protein, gamma 2, 47kDa (GJC2) (AA 53-78), (N-Term) antibodyGJC2 适用: 人 WB 宿主: 小鼠 Monoclonal 391CT6-4-3 unconjugated
anti-Gap Junction Protein, gamma 2, 47kDa (GJC2) (AA 21-70) antibodyGJC2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
WB: 1:200
FC: The optimal concentration should be determined by the user
ICC: The optimal concentration should be determined by the user
IHC: 1:300
IP: The optimal concentration should be determined by the user
-
说明
-
Negative Control: (ABIN7235562)
Blocking Peptide: (ABIN7235562)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
-
浓度
- 0.8 mg/mL
-
缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
-
-
- GJC2 (Gap Junction Protein, gamma 2, 47kDa (GJC2))
-
别名
- GJC2
-
背景
-
Synonyms: CX47, Gap Junction Gamma-2 Protein, Gap Junction Alpha-12 Protein, GJA12, Connexin-46.6
Description: Connexin-47 (Cx47) is a gap junction (GJ) protein expressed in the Central nervous system.It belongs to the connexins family of transmembrane proteins. Proteins that belong to this family form intercellular membrane channels that allow diffusional movement of ions, metabolites, and signaling molecules. The family members are composed of four transmembrane segments, an unstructured C and N cytoplasmic termini, a cytoplasmic loop and two extra-cellular loops1.Connexins oligomerize among the family members to form different structures and Cx47 was shown to form gap junction channels together with Cx43.These voltage gated channels exhibit ionic and chemical rectification, which creates a directional diffusion barrier for the movement of ions and negatively charged molecules from cells expressing Cx47 to those with Cx431.The channel mediates an intercellular communication between oligodendrocytes and between astrocytes. This process is essential to maintain the integrity of myelin and maintaining K+ buffering and nutrient homeostasis in oligodendrocytes, myelin and oligodendrocyte function2,3, and indeed, mutations in human Cx47 cause severe myelin disorders2.Cx43/Cx47 gap junction channels activity was shown to be associated with the development of Multiple Sclerosis and autoimmune demyelination, underscoring a critical role for Cx47 in regulating neuroinflammation4.
-
基因ID
- 57165
-
NCBI登录号
- NM_020435
-
UniProt
- Q80XF7
抗原
-
