GPR50 抗体 (Intracellular)
Quick Overview for GPR50 抗体 (Intracellular) (ABIN7237666)
抗原
See all GPR50 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 307-321, Intracellular
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原理
- A Rabbit Polyclonal antibody to GPR50
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特异性
- Intracellular, C-terminus.
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交叉反应
- 小鼠, 大鼠
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预测反应
- Rat - identical,Human - 14 out of 15 amino acid residues identical
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产品特性
- Intracellular, C-terminus
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
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Immunogen: Synthetic peptide
Immunogen Sequence: (C)ESFRREYWTIFHAMR, corresponding to amino acid residues 307 - 321 of mouse GPR50
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亚型
- IgG
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anti-G Protein-Coupled Receptor 50 (GPR50) (C-Term) antibody
GPR50 适用: 人, 猴 IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 50 (GPR50) (Cytoplasmic Domain) antibodyGPR50 适用: 人, 猴, 犬, 绵羊 IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 50 (GPR50) (AA 1-617) antibodyGPR50 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 50 (GPR50) (Internal Region) antibodyGPR50 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 50 (GPR50) (AA 1-617) antibodyGPR50 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 50 (GPR50) (C-Term) antibodyGPR50 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 50 (GPR50) (AA 316-344) antibodyGPR50 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB24002 unconjugated
anti-G Protein-Coupled Receptor 50 (GPR50) (C-Term) antibodyGPR50 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 50 (GPR50) (AA 323-352), (Middle Region) antibodyGPR50 适用: 人 WB, FACS, EIA 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 50 (GPR50) (Internal Region) antibodyGPR50 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A
Application Dilutions Western blot wb: 1:200
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说明
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Negative Control: (ABIN7235419)
Blocking Peptide: (ABIN7235419)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 0.2 mL double distilled water (DDW).
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浓度
- 1 mg/mL
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缓冲液
- PBS pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
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Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
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- GPR50 (G Protein-Coupled Receptor 50 (GPR50))
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别名
- GPR50
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背景
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G Protein-Coupled Receptor 50, Melatonin-Related Receptor,G protein-coupled receptor 50 (GPR50), previously known as the melatonin-related receptor, share 45 % sequence identity to melatonin receptors MT1 and MT2 but it does not bind melatonin or any other known ligand and therefore remains an orphan receptor without a clear function1,2.GPR50 belongs to the G protein coupled receptors (GPCRs) family, a large group of receptors characterized by seven trans membrane helices that transmit a signal from the outside cellular surface into the inside of the cell through conformational changes. GPCRs mediate most of the physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases1.GPR50 was identified as a risk gene for bipolar disorder and major depression and it was shown to have a role in neural development and sterol metabolism, it was also shown to be related to mood disorders, adaptive thermogenesis and torpor response (the body's response to starvation)2. In addition, it was shown to have a dramatic effect on neurite outgrowth, supporting a likely role in neural development and it was also found to be expressed in various types of cancer3.GPR50 is expressed in the pituitary, hypothalamus, cortex, midbrain, pons, amygdala, and in several brainstem nuclei3,4. Due to its involvement in a wide range of mental conditions and disease, GPR50 is a major target for research and drug development.
Alternative names: G Protein-Coupled Receptor 50, Melatonin-Related Receptor -
基因ID
- 14765
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NCBI登录号
- NM_004224
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UniProt
- O88495
抗原
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