GPR139 抗体 (Intracellular)
Quick Overview for GPR139 抗体 (Intracellular) (ABIN7237648)
抗原
See all GPR139 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 204-217, Intracellular
-
原理
- A Rabbit Polyclonal antibody to Parkin
-
特异性
- Intracellular, 3rd loop.
-
交叉反应
- 人, 小鼠, 大鼠
-
预测反应
- Rat,Human - identical
-
产品特性
- Intracellular, 3rd loop
-
纯化方法
- Affinity purified on immobilized antigen.
-
免疫原
-
Immunogen: Synthetic peptide
Immunogen Sequence: (C)RKSNFRLRGYSTGK, corresponding to amino acid residues 204 - 217 of mouse GPR139
-
亚型
- IgG
-
-
anti-G Protein-Coupled Receptor 139 (GPR139) (Cytoplasmic Domain) antibody
GPR139 适用: 人, 小鼠, 大鼠, 犬, 马, 猴, 兔, 小鸡, Cow IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 139 (GPR139) antibodyGPR139 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 139 (GPR139) (Transmembrane Domain) antibodyGPR139 适用: 人, 小鼠, 大鼠, 犬, 马, 猴, 兔, Hamster, Pig IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 139 (GPR139) (Cytoplasmic Domain) antibodyGPR139 适用: 人, 小鼠, 大鼠, 犬, 马, 猴, 兔, 小鸡, Cow, Hamster, Pig, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 139 (GPR139) (Internal Region) antibodyGPR139 适用: 人 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 139 (GPR139) (Internal Region) antibodyGPR139 适用: 人, 小鼠, 大鼠 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 139 (GPR139) (3rd Cytoplasmic Domain) antibodyGPR139 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 139 (GPR139) (Internal Region) antibodyGPR139 适用: 人, 小鼠, 大鼠 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-G Protein-Coupled Receptor 139 (GPR139) (AA 181-230) antibodyGPR139 适用: 人, 小鼠, 大鼠 ELISA, IF 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Antigen preadsorption control: 1 μg peptide per 1 μg antibody
Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:600
Application Dilutions Western blot wb: 1:200-1:800
-
说明
-
Negative Control: (ABIN7235369)
Blocking Peptide: (ABIN7235369)
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
-
浓度
- 1 mg/mL
-
缓冲液
- PBS pH 7.4
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.
Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
-
-
- GPR139 (G Protein-Coupled Receptor 139 (GPR139))
-
别名
- GPR139
-
背景
-
G Protein-Coupled Receptor 139, PGR3, G(Q)-Coupled Orphan Receptor GPRg1, GPRG1,G-protein-coupled receptors (GPCRs), are the largest family of membrane proteins and mediate most of the physiological responses to hormones, neurotransmitters and environmental stimulants. At the most basic level, all GPCRs are characterized by the presence of seven membrane-spanning α-helical segments separated by alternating intracellular and extracellular loop regions1. Orphan GPCRs are a group of GPCRs that their endogenous ligands remain unidentified and therefore their natural functions in doubt2.GPR139 is an orphan GPCRs for which amino acids L-tryptophan and L-phenylalanine, the adrenocorticotropic hormone (ACTH), and α- and β-melanocyte-stimulating hormone have been proposed as endogenous agonists3. GPR139 was found to be highly conserved across species, as the amino acid sequence of the human GPR139 protein is 96 % , 92 % and 70 % identical to the mouse, chicken and zebrafish orthologs, respectively. According to mRNA expression levels GPR139 is mainly expressed in the central nervous system (CNS). GPR139 has been reported to activate several G protein pathways of which Gq/11 is the primary one4.
Alternative names: G Protein-Coupled Receptor 139, PGR3, G(Q)-Coupled Orphan Receptor GPRg1, GPRG1 -
基因ID
- 209776
-
NCBI登录号
- NM_001002911
-
UniProt
- Q80UC8
抗原
-
