Becn2 抗体
The 兔 多克隆 anti-Becn2 antibody (ABIN7232892) specifically detects Becn2 in WB 和 IF/ICC.
The antibody is reactive with 人 samples.
产品编号 ABIN7232892
发货至:
中国
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中国
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北京 101111
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Quick Overview for Becn2 抗体 (ABIN7232892)
抗原
Becn2
适用
人
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
Western Blotting (WB), Immunofluorescence (fixed cells) (IF/ICC)
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原理
- Anti-Beclin2 Rabbit Polyclonal Antibody
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特异性
- This antibody recognizes human and rat Beclin 2.
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交叉反应
- 人, 大鼠
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免疫原
- Synthetic peptide corresponding to mid-protein amino acids of human Beclin 2.
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anti-Becn2 (N-Term) antibody
适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunoblotting: use at 1-2 μg/mL. A band of ~50 kDa is detected.Detection of Beclin 2 in 20 μg rat liver lysate.
These are recommended concentrations.
Endusers should determine optimal concentrations for their applications. -
限制
- 仅限研究用
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状态
- Liquid
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溶解方式
- Dilute in PBS or medium that is identical to that used in the assay system.
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浓度
- 1.0 mg/mL
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缓冲液
- PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- This antibody is stable for at least one (1) year at -20°C.
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- Becn2
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背景
- Beclin-2,Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1. {PubMed:23954414}.,Autophagy is a catabolic process that results in the degradation of bulk cytoplasmic contents within autophagosomes and lysosomes. Beclin 2 is an Atg6/Beclin family member that functions in two distinct lysosomal degradation pathways, autophagy and the downregulation of certain seven- transmembrane-spanning GPCRs. Its role in GPCR lysosomal degradation does not involve Beclin 1 or other Beclin 1/2-interacting proteins such as ATG14 and VPS34 that function in autophagy. Its role in lysosomal degradation also appears to differ from other autophagy- independent functions previously described for yeast Atg6/Vps30 or mammalian Beclin 1, such as vacuolar protein sorting and EGFR degradation.,Cytoplasm,Beclin-1 autophagy-related pseudogene 1, Beclin-1-like protein 1
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UniProt
- A8MW95
抗原
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