Becn2 抗体
适用: 人
WB, IF/ICC
宿主: 兔
Polyclonal
unconjugated
-
- 抗原
- Becn2
- 适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- 非结合性
-
应用范围
- Western Blotting (WB), Immunofluorescence (fixed cells) (IF/ICC)
- 原理
- Anti-Beclin2 Rabbit Polyclonal Antibody
- 特异性
- This antibody recognizes human and rat Beclin 2.
- 交叉反应
- 人, 大鼠
- 免疫原
- Synthetic peptide corresponding to mid-protein amino acids of human Beclin 2.
-
anti-Becn2 (N-Term) antibody
适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
Immunoblotting: use at 1-2 μg/mL. A band of ~50 kDa is detected.Detection of Beclin 2 in 20 μg rat liver lysate.
These are recommended concentrations.
Endusers should determine optimal concentrations for their applications. - 限制
- 仅限研究用
-
- 状态
- Liquid
- 溶解方式
- Dilute in PBS or medium that is identical to that used in the assay system.
- 浓度
- 1.0 mg/mL
- 缓冲液
- PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- This antibody is stable for at least one (1) year at -20°C.
-
- 抗原
- Becn2
- 别名
- Beclin-2 antibody, Gm104 antibody, beclin 2 antibody, Becn2 antibody
- 背景
- Beclin-2,Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1. {PubMed:23954414}.,Autophagy is a catabolic process that results in the degradation of bulk cytoplasmic contents within autophagosomes and lysosomes. Beclin 2 is an Atg6/Beclin family member that functions in two distinct lysosomal degradation pathways, autophagy and the downregulation of certain seven- transmembrane-spanning GPCRs. Its role in GPCR lysosomal degradation does not involve Beclin 1 or other Beclin 1/2-interacting proteins such as ATG14 and VPS34 that function in autophagy. Its role in lysosomal degradation also appears to differ from other autophagy- independent functions previously described for yeast Atg6/Vps30 or mammalian Beclin 1, such as vacuolar protein sorting and EGFR degradation.,Cytoplasm,Beclin-1 autophagy-related pseudogene 1, Beclin-1-like protein 1
- UniProt
- A8MW95
-
You are here:
