SCNN1B 抗体 (C-Term)
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Quick Overview for SCNN1B 抗体 (C-Term) (ABIN7232816)
抗原
See all SCNN1B 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 617-638, C-Term
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原理
- Anti-ENaC beta Mouse Monoclonal Antibody
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特异性
- Mouse ENaC beta
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交叉反应
- 小鼠
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免疫原
- Synthetic peptide corresponding to C-terminal aa 617-638 of rat ENaC alpha.
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亚型
- IgG1
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应用备注
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Immunoblotting: use at 1 μg/mL.
Immunohistochemistry: use at 5-10 μg/mL.
Endusers should determine optimal concentrations for their applications. -
限制
- 仅限研究用
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状态
- Liquid
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溶解方式
- Dilute in PBS or medium that is identical to that used in the assay system.
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浓度
- 1.0 mg/mL
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缓冲液
- PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- This antibody is stable for at least one (1) year at -20°C.
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- SCNN1B (Sodium Channel, Nonvoltage-Gated 1, beta (SCNN1B))
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别名
- Scnn1b
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背景
- Amiloride-sensitive sodium channel subunit beta,Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride (PubMed:9118951). Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. {UniProtKB:P51168, PubMed:9118951}.,The epithelial sodium channel (ENaC) is a membrane-bound ion-channel that is selectively permeable to Na+ ions and that is assembled as a heterotrimer composed of three homologous subunits alpha, beta, and g. It is involved primarily in the reabsorption of sodium ions in the collecting ducts of the kidney's nephrons. These channels mediate the first step of active sodium reabsorption essential for the maintenance of body salt and water homeostasis. In vertebrates, the channels control reabsorption of sodium in kidney, colon, lung and sweat glands, they also play a role in taste perception.,Apical cell membrane, Cytoplasmic vesicle membrane,Beta-NaCH, Epithelial Na(+ channel subunit beta, Beta-ENaC, Nonvoltage-gated sodium channel 1 subunit beta, SCNEB
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NCBI登录号
- NP_036780
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UniProt
- P37090
抗原
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