NALCN 抗体 (C-Term)
Quick Overview for NALCN 抗体 (C-Term) (ABIN7232810)
抗原
See all NALCN 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1659-1738, C-Term
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原理
- Anti-NALCN Mouse Monoclonal Antibody
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特异性
- This antibody recognizes mouse and rat NALCN.
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交叉反应
- 小鼠, 大鼠
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纯化方法
- Purified by Protein G affinity chromatography.
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免疫原
- Fusion protein corresponding to aa 1659-1738 (cytoplasmic C- terminus) of rat NALCN (accession no.Q6Q760).
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亚型
- IgG1
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anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody
NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 unconjugated
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (HRP)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 HRP
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (FITC)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 FITC
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (Biotin)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 Biotin
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (PE)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 PE
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (PerCP)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 PerCP
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (APC)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 APC
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (Atto 488)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 Atto 488
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (Atto 594)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 Atto 594
anti-Sodium Leak Channel, Non-Selective (NALCN) (AA 1659-1738) antibody (Atto 390)NALCN 适用: 大鼠 WB, ICC, IF 宿主: 小鼠 Monoclonal S187-7 Atto 390
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应用备注
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Immunoblotting: use at 1 μg/mL. Predicted molecular weight is ~200 kDa.
Positive control: rat brain lysate.
These are recommended concentrations.
Endusers should determine optimal concentrations for their applications. -
限制
- 仅限研究用
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状态
- Liquid
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溶解方式
- Dilute in PBS or medium which is identical to that used in the assay system.
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浓度
- 1.0 mg/mL
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缓冲液
- PBS, pH 7.4, 50 % glycerol, 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- This antibody is stable for at least one (1) year at -20°C.
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- NALCN (Sodium Leak Channel, Non-Selective (NALCN))
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别名
- Nalcn
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背景
- Sodium leak channel NALCN,Voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability. NALCN channel functions as a multi-protein complex, which consists at least of NALCN, NALF1, UNC79 and UNC80. NALCN is the voltage-sensing, pore-forming subunit of the NALCN channel complex. NALCN channel complex is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations (By similarity). In addition to its role in regulating neuronal excitability, is required for normal respiratory rhythm, systemic osmoregulation by controlling the serum sodium concentration and in the regulation of the intestinal pace-making activity in the interstitial cells of Cajal. NALCN channel is also activated by neuropeptides such as neurotensin and substance P (SP) through a SRC family kinases-dependent pathway. In addition, NALCN activity is enhanced/modulated by several GPCRs, such as CHRM3 (By similarity). {UniProtKB:Q8BXR5, UniProtKB:Q8IZF0}.,NALCN (sodium leak channel non- selective protein) is a 1,738 amino acid multi-pass membrane protein in the cation-nonselective channel family. NALCN is highly conserved in mammalian species and is widely expressed in the central nervous system. NALCN is a voltage-independent, non-selective cation channel which is permeable to sodium, potassium, and calcium ions. It is responsible for background sodium ion leak conductance in neurons and regulates basal excitability of the nervous system. Three isoforms of NALCN result from alternative splicing events.,Cell membrane, Multi-pass membrane protein,Four domain-type voltage-gated ion channel α-1 subunit, Rb21-channel, Sodium leak channel non-selective protein, Voltage gated channel-like protein 1
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NCBI登录号
- NP_705894
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UniProt
- Q6Q760
抗原
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