USP11 抗体 (Internal Region)
Quick Overview for USP11 抗体 (Internal Region) (ABIN7218842)
抗原
See all USP11 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Internal Region
-
原理
- USP11 Polyclonal Antibody
-
特异性
- USP11 Polyclonal Antibody detects endogenous levels of USP11 protein.
-
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
-
免疫原
- Synthesized peptide derived from the Internal region of human USP11
-
亚型
- IgG
-
-
-
-
应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:20000). Not yet tested in other applications.
-
说明
-
Primary Antibody
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
-
-
- USP11 (Ubiquitin Specific Peptidase 11 (USP11))
-
别名
- USP11
-
背景
- Rabbit Anti-USP11 Polyclonal Antibody,USP11, UHX1, Ubiquitin carboxyl-terminal hydrolase 11, Deubiquitinating enzyme 11, Ubiquitin thioesterase 11, Ubiquitin-specific-processing protease 11,USP11 (Ubiquitin Specific Peptidase 11) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Chaperonin-mediated protein folding. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP4. rotease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed: 12084015, PubMed: 15314155, PubMed: 17897950, PubMed: 19874889, PubMed: 20233726, PubMed: 24724799). Inhibits the degradation of target proteins by the proteasome (PubMed: 12084015). Cleaves preferentially Lys-6 and Lys-63-linked ubiquitin chains. Has lower activity with Lys-11 and Lys-33-linked ubiquitin chains, and extremely low activity with Lys-27, Lys-29 and Lys-48-linked ubiquitin chains (in vitro) (PubMed: 24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed: 17897950, PubMed: 19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed: 15314155, PubMed: 20233726).,Ubiquitin carboxyl-terminal hydrolase 11
-
分子量
- observerd band 105kDa
-
UniProt
- P51784
抗原
-