TTR 抗体
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北京 101111
Quick Overview for TTR 抗体 (ABIN7212312)
抗原
See all TTR 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Mouse Anti-TTR Mouse Monoclonal Antibody (1D7)
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特异性
- The antibody detects endogenous TTR protein.
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纯化方法
- The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Recombinant Protein of TTR
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亚型
- IgG1
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF 1:50-200,WB 1:500-2000,IHC 1:50-300
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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有效期
- 12 months
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- TTR (Transthyretin (TTR))
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别名
- TTR
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背景
- Transthyretin, ATTR, Prealbumin, TBPATTR (transthyretin) encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein, it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in TTR have been reported, most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.
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分子量
- 16kD
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基因ID
- 7276
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UniProt
- P02766
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途径
- Hormone Transport
抗原
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