TMC8 抗体 (AA 570-650)
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北京 101111
Quick Overview for TMC8 抗体 (AA 570-650) (ABIN7219788)
抗原
See all TMC8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 570-650
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原理
- Rabbit Anti-TMC8 Polyclonal Antibody
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特异性
- TMC8 Polyclonal Antibody detects endogenous levels of TMC8 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- Synthesized peptide derived from the C-terminal region of human TMC8 at AA range: 570-650
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:5000,IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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有效期
- 12 months
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- TMC8 (Transmembrane Channel-Like 8 (TMC8))
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别名
- TMC8
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背景
- TMC8, EVER2, EVIN2, Transmembrane channel-like protein 8, Epidermodysplasia verruciformis protein 2Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. TMC8 encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs.
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分子量
- 81kD
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基因ID
- 147138
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UniProt
- Q8IU68
抗原
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