TOP2B 抗体 (AA 10-90)
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北京 101111
Quick Overview for TOP2B 抗体 (AA 10-90) (ABIN7224754)
抗原
See all TOP2B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 10-90
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原理
- Topo IIβ Polyclonal Antibody
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特异性
- Topo IIβ Polyclonal Antibody detects endogenous levels of Topo IIβ protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the N-terminal region of human Topo IIbeta at AA range: 10-90
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亚型
- IgG
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anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (AA 446-655) antibody
TOP2B 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (N-Term) antibodyTOP2B 适用: 人, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (C-Term) antibodyTOP2B 适用: 人 WB, IF, IP, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (AA 1400-1626) antibodyTOP2B 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (N-Term) antibodyTOP2B 适用: 人, 犬, 猴, Pig WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (AA 1411-1523) antibodyTOP2B 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (C-Term) antibodyTOP2B 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (AA 1548-1597) antibodyTOP2B 适用: 人, 小鼠, 大鼠, 犬, 猴, Pig, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (AA 1439-1488) antibodyTOP2B 适用: 人, 小鼠, 大鼠, 犬, 猴, Pig, 豚鼠, 马, 兔, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Topoisomerase (DNA) II beta 180kDa (TOP2B) (Middle Region) antibodyTOP2B 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- TOP2B (Topoisomerase (DNA) II beta 180kDa (TOP2B))
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别名
- Topo IIbeta
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背景
- Rabbit Anti-Topo IIβ Polyclonal Antibody,TOP2B, DNA topoisomerase 2-beta, DNA topoisomerase II, beta isozyme,TOP2B (topoisomerase (DNA) II beta) encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. TOP2B encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in TOP2B have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of TOP2B results in two transcript variants, however, the second variant has not yet been fully described.,DNA topoisomerase 2-beta
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分子量
- observerd band 183kDa
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基因ID
- 7155
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UniProt
- Q02880
抗原
-
