Topo IIalpha (pSer1106) 抗体
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北京 101111
Quick Overview for Topo IIalpha (pSer1106) 抗体 (ABIN7224744)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer1106
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原理
- Topo IIα (phospho Ser1106) Polyclonal Antibody
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特异性
- Phospho-Topo IIα (S1106) Polyclonal Antibody detects endogenous levels of Topo IIα protein only when phosphorylated at S1106.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from human Topo IIalpha Phospho-Ser1106
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亚型
- IgG
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anti-Topo IIalpha (N-Term) antibody
适用: 人, 猴 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Topo IIalpha (pThr1343) antibody适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Topo IIalpha (pSer1525) antibody适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:5000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- Topo IIalpha
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背景
- Rabbit Anti-Topo IIα (phospho Ser1106) Polyclonal Antibody,TOP2A, TOP2, DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme,TOP2A (topoisomerase (DNA) II alpha) encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. TOP2A encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.,DNA topoisomerase 2-alpha
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分子量
- observerd band 174kDa
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基因ID
- 7153
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UniProt
- P11388
抗原
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