Titin 抗体 (AA 161-210)
Quick Overview for Titin 抗体 (AA 161-210) (ABIN7231962)
抗原
See all Titin (TTN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 161-210
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原理
- TTN Polyclonal Antibody
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特异性
- The antibody detects endogenous levels of TTN
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen
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免疫原
- Synthesized peptide derived from part region of human TTN protein at AA range: 161-210
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亚型
- IgG
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anti-Titin (TTN) (AA 1-110) antibody
TTN 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2B3 unconjugated
anti-Titin (TTN) (AA 1-110) antibodyTTN 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 7D3 unconjugated
anti-Titin (TTN) (AA 2670-2703) antibodyTTN 适用: 人, 大鼠, 小鼠 ELISA, FACS, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Titin (TTN) (AA 33779-34025) antibodyTTN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Titin (TTN) (AA 5398-5604) antibodyTTN 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Titin (TTN) (AA 7169-7203), (N-Term) antibodyTTN 适用: 人 IHC (p) 宿主: 兔 Polyclonal RB49137 unconjugated
anti-Titin (TTN) (AA 1-110) antibodyTTN 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F12 unconjugated
anti-Titin (TTN) (AA 33779-34025) antibodyTTN 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Titin (TTN) (AA 1-110) antibodyTTN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Titin (TTN) antibodyTTN 适用: 大鼠, 小鼠 IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:50-1:200), ELISA (1:10000-1:20000).
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol as stabilizer.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- Titin (TTN)
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别名
- TTN
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背景
- Rabbit Anti-TTN Polyclonal Antibody,Titin, Connectin, Rhabdomyosarcoma antigen MU-RMS-40.14,TTN encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in TTN are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma.,TTN
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基因ID
- 7273
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UniProt
- Q8WZ42
抗原
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