TGIF1 抗体 (C-Term)
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Quick Overview for TGIF1 抗体 (C-Term) (ABIN7224686)
抗原
See all TGIF1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- TGIF Polyclonal Antibody
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特异性
- TGIF Polyclonal Antibody detects endogenous levels of TGIF protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the C-terminal region of human TGIF
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- TGIF1 (TGFB-Induced Factor Homeobox 1 (TGIF1))
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别名
- TGIF
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背景
- Rabbit Anti-TGIF Polyclonal Antibody,TGIF1, TGIF, Homeobox protein TGIF1, 5'-TG-3'-interacting factor 1,The protein encoded by TGIF1 (TGFB induced factor homeobox 1) is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in TGIF1 are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described.,Homeobox protein TGIF1
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分子量
- observerd band 43kDa
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基因ID
- 7050
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UniProt
- Q15583
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途径
- Retinoic Acid Receptor Signaling Pathway, Chromatin Binding, Tube Formation
抗原
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