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TERT 抗体 (pSer227)

This 兔 多克隆 anti-TERT antibody specifically detects TERT in ELISA 和 IF. The antibody is reactive with 人 samples.
产品编号 ABIN7224664
发货至: 中国
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Quick Overview for TERT 抗体 (pSer227) (ABIN7224664)

抗原

See all TERT 抗体
TERT (Telomerase Reverse Transcriptase (TERT))

适用

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宿主

  • 116
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克隆类型

  • 97
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多克隆

标记

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This TERT antibody is un-conjugated

应用范围

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ELISA, Immunofluorescence (IF)
  • 抗原表位

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    pSer227

    原理

    TERT (phospho Ser227) Polyclonal Antibody

    特异性

    Phospho-TERT (S227) Polyclonal Antibody detects endogenous levels of TERT protein only when phosphorylated at S227.

    纯化方法

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

    免疫原

    Synthesized peptide derived from human TERT Phospho-Ser227

    亚型

    IgG
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF (1:200-1:1000), ELISA (1:10000). Not yet tested in other applications.

    说明

    Primary Antibody

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
  • 抗原

    TERT (Telomerase Reverse Transcriptase (TERT))

    别名

    TERT

    背景

    Rabbit Anti-TERT (phospho Ser227) Polyclonal Antibody,TERT, EST2, TCS1, TRT, Telomerase reverse transcriptase, HEST2, Telomerase catalytic subunit, Telomerase-associated protein 2, TP2,Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified, the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.,Telomerase reverse transcriptase

    基因ID

    7015

    UniProt

    O14746

    途径

    Telomere Maintenance
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