TBC1D4 抗体
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Quick Overview for TBC1D4 抗体 (ABIN7226136)
抗原
See all TBC1D4 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- TBC1D4 Polyclonal Antibody
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特异性
- TBC1D4 Polyclonal Antibody detects endogenous levels of TBC1D4 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from human TBC1D4 around the non-phosphorylation site of T642
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亚型
- IgG
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anti-TBC1 Domain Family, Member 4 (TBC1D4) (AA 574-712) antibody
TBC1D4 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 8A11A2 unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (AA 1-94) antibodyTBC1D4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) antibodyTBC1D4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (Internal Region) antibodyVerified TBC1D4 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (AA 172-201), (N-Term) antibodyTBC1D4 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB21034 unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (pSer642) antibodyTBC1D4 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (pThr642) antibodyTBC1D4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) antibodyTBC1D4 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB890 unconjugated Recombinant Antibody
anti-TBC1 Domain Family, Member 4 (TBC1D4) (AA 1155-1204) antibodyTBC1D4 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TBC1 Domain Family, Member 4 (TBC1D4) (pThr642) antibodyTBC1D4 适用: 人, 小鼠 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:10000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))
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别名
- TBC1D4
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背景
- Rabbit Anti-TBC1D4 Polyclonal Antibody,TBC1D4, AS160, KIAA0603, TBC1 domain family member 4, Akt substrate of 160 kDa, AS160,TBC1D4 (TBC1 domain family member 4) is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by TBC1D4 is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms.,TBC1 domain family member 4
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基因ID
- 9882
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UniProt
- O60343
抗原
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