TCL1A 抗体 (AA 30-110)
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北京 101111
Quick Overview for TCL1A 抗体 (AA 30-110) (ABIN7231744)
抗原
See all TCL1A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 30-110
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原理
- Tcl1 Polyclonal Antibody
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特异性
- The antibody detects endogenous levels of Tcl1
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纯化方法
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen
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免疫原
- Synthesized peptide derived from part region of human Tcl1 protein at AA range: 30-110
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000-1:20000).
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol as stabilizer.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- TCL1A (T-Cell Leukemia/lymphoma 1A (TCL1A))
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别名
- Tcl1
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背景
- Rabbit Anti-Tcl1 Polyclonal Antibody,T-cell leukemia/lymphoma protein 1A, Oncogene TCL-1, Oncogene TCL1, Protein p14 TCL1,Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al. 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) TCL1A (T-Cell Leukemia/Lymphoma 1A) is a Protein Coding gene. Diseases associated with TCL1A include Precursor T-Cell Acute Lymphoblastic Leukemia and T-Cell Leukemia. Among its related pathways are PI3K-Akt signaling pathway and PI3K / Akt Signaling. An important paralog of TCL1A is MTCP1.,Tcl1
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分子量
- observerd band 13kDa
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基因ID
- 8115
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UniProt
- P56279
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途径
- Stem Cell Maintenance
抗原
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