TAL1 抗体 (pSer122)
Our Local Distributor
北京 101111
Quick Overview for TAL1 抗体 (pSer122) (ABIN7224604)
抗原
See all TAL1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- pSer122
-
原理
- TAL1 (phospho Ser122) Polyclonal Antibody
-
特异性
- Phospho-TAL1 (S122) Polyclonal Antibody detects endogenous levels of TAL1 protein only when phosphorylated at S122.
-
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
-
免疫原
- Synthesized peptide derived from human TAL1 Phospho-Ser122
-
亚型
- IgG
-
-
-
-
应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:10000). Not yet tested in other applications.
-
说明
-
Primary Antibody
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
-
-
- TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))
-
别名
- TAL1
-
背景
- Rabbit Anti-TAL1 (phospho Ser122) Polyclonal Antibody,TAL1, BHLHA17, SCL, TCL5, T-cell acute lymphocytic leukemia protein 1, TAL-1, Class A basic helix-loop-helix protein 17, bHLHa17, Stem cell protein, T-cell leukemia/lymphoma protein 5,The basic helix-loop-helix (bHLH) family of transcription factors play roles in a variety of developmental and adult biological settings. The basic (b) domain of bHLH transcription factors allows association with DNA, while the HLH domain facilitates the mono- and heterodimeric interactions required for efficient DNA binding. TAL1, also known as SCL, is a bHLH transcription factor that plays an essential role in the generation of embryonic hematopoietic stem cells , and is required for maturation of erythroid and megakaryocytic lineages in the adult. TAL1 interacts with Lim-domain containing proteins LMO2 and Ldb1, and has been found in complexes with these proteins as well as the hematopoietic transcription factor GATA-1. Both TAL1 and LMO2 have been associated with T-cell acute lymphoblastic leukemia (T-ALL). TAL1 activity is essential for both hematopoiesis and neurogenesis.,T-cell acute lymphocytic leukemia protein 1
-
分子量
- observerd band 45kDa
-
基因ID
- 6886
-
UniProt
- P17542
-
途径
- Stem Cell Maintenance
抗原
-