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TAL1 抗体 (pSer122)

The 兔 多克隆 anti-TAL1 antibody (ABIN7224604) specifically detects TAL1 in WB, ELISA 和 IHC (p). The antibody is reactive with 人 和 小鼠 samples.
产品编号 ABIN7224604
发货至: 中国
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Quick Overview for TAL1 抗体 (pSer122) (ABIN7224604)

抗原

See all TAL1 抗体
TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

适用

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人, 小鼠

宿主

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克隆类型

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多克隆

标记

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This TAL1 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

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    pSer122

    原理

    TAL1 (phospho Ser122) Polyclonal Antibody

    特异性

    Phospho-TAL1 (S122) Polyclonal Antibody detects endogenous levels of TAL1 protein only when phosphorylated at S122.

    纯化方法

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

    免疫原

    Synthesized peptide derived from human TAL1 Phospho-Ser122

    亚型

    IgG
  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:10000). Not yet tested in other applications.

    说明

    Primary Antibody

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
  • 抗原

    TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

    别名

    TAL1

    背景

    Rabbit Anti-TAL1 (phospho Ser122) Polyclonal Antibody,TAL1, BHLHA17, SCL, TCL5, T-cell acute lymphocytic leukemia protein 1, TAL-1, Class A basic helix-loop-helix protein 17, bHLHa17, Stem cell protein, T-cell leukemia/lymphoma protein 5,The basic helix-loop-helix (bHLH) family of transcription factors play roles in a variety of developmental and adult biological settings. The basic (b) domain of bHLH transcription factors allows association with DNA, while the HLH domain facilitates the mono- and heterodimeric interactions required for efficient DNA binding. TAL1, also known as SCL, is a bHLH transcription factor that plays an essential role in the generation of embryonic hematopoietic stem cells , and is required for maturation of erythroid and megakaryocytic lineages in the adult. TAL1 interacts with Lim-domain containing proteins LMO2 and Ldb1, and has been found in complexes with these proteins as well as the hematopoietic transcription factor GATA-1. Both TAL1 and LMO2 have been associated with T-cell acute lymphoblastic leukemia (T-ALL). TAL1 activity is essential for both hematopoiesis and neurogenesis.,T-cell acute lymphocytic leukemia protein 1

    分子量

    observerd band 45kDa

    基因ID

    6886

    UniProt

    P17542

    途径

    Stem Cell Maintenance
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