SOCS2 抗体 (Internal Region)
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Quick Overview for SOCS2 抗体 (Internal Region) (ABIN7217074)
抗原
See all SOCS2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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原理
- SOCS-2 Polyclonal Antibody
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特异性
- SOCS-2 Polyclonal Antibody detects endogenous levels of SOCS-2 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from the Internal region of human SOCS-2
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))
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别名
- SOCS-2
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背景
- Rabbit Anti-SOCS-2 Polyclonal Antibody,SOCS2, CIS2, SSI2, STATI2, Suppressor of cytokine signaling 2, SOCS-2, Cytokine-inducible SH2 protein 2, CIS-2, STAT-induced STAT inhibitor 2, SSI-2,SOCS2 encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. Suppressor of cytokine signaling 2 encoded by SOCS2 interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants.,Suppressor of cytokine signaling 2
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分子量
- observerd band 22kDa
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基因ID
- 8835
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UniProt
- O14508
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途径
- JAK/STAT Signaling, Response to Growth Hormone Stimulus
抗原
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